Klea Scott began her television career in Steven Bochco's series Brooklyn South. Other television roles include Chris Carter's critically-acclaimed series Millennium and Michael Mann's series Robbery Homicide Division, The Cosby Show, Just Shoot Me, In Justice, ER, Century City, Medical Investigation, and the historical drama Sally Hemmings: An American Scandal.

In feature film, Scott has worked with many directors including Steven Spielberg in Minority Report and Michael Mann in Collateral. Scott also has starred in the independent films Manfast and Lullabye.

Scott began her acting career in theater appearing in numerous NYC productions from Williamstown to Shakespeare in the Park and had her conservatory training at the North Carolina School of the Arts where she received her Bachelor of Fine Arts. She continues to return to the stage at every opportunity. In 2003, she starred opposite Tony winner Jefferson Mays in Des McAnuff's production of Tartuffe at the La Jolla Playhouse and also starred in Jon Robin Baitz Ten Unknowns at the Mark Taper Forum. She starred in the Maui Onstage's 2004 production of Sweet Charity directed by her husband, theater director John Langs.